Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns.

@article{Smith1993ScanningAC,
  title={Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns.},
  author={Christopher W. J. Smith and Tanya T W Chu and Bernardo Nadal-Ginard},
  journal={Molecular and cellular biology},
  year={1993},
  volume={13 8},
  pages={4939-52}
}
In mammalian intron splicing, the mechanism by which the 3' splice site AG is accurately and efficiently identified has remained unresolved. We have previously proposed that the 3' splice site in mammalian introns is located by a scanning mechanism for the first AG downstream of the branch point-polypyrimidine tract. We now present experiments that lend further support to this model while identifying conditions under which competition can occur between adjacent AGs. The data show that the 3… CONTINUE READING
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