Scaling up an electrochemical signal with a catalytic hairpin assembly coupling nanocatalyst label for DNA detection.

@article{Hun2015ScalingUA,
  title={Scaling up an electrochemical signal with a catalytic hairpin assembly coupling nanocatalyst label for DNA detection.},
  author={Xu Hun and Guoliang Xie and Xiliang Luo},
  journal={Chemical communications},
  year={2015},
  volume={51 33},
  pages={
          7100-3
        }
}
A strategy for the electrochemical detection of DNA based on catalytic hairpin assembly combined with nanocatalyst label-based redox cycling reaction signal amplification. A superior detection limit of 0.3 aM toward DNA can be achieved. 

Figures from this paper

DNA base-stacking assay utilizing catalytic hairpin assembly-induced gold nanoparticle aggregation for colorimetric protein sensing.
A label-free and enzyme-free colorimetric sensing platform for the amplified detection of fibronectin was developed based on an ingenious combination of catalytic hairpin assembly and a base stacking
Ultrasensitive supersandwich-type biosensor for enzyme-free amplified microRNA detection based on N-doped graphene/Au nanoparticles and hemin/G-quadruplexes.
TLDR
This biosensor platform successfully realized the combination of the signal amplification technique with the supersandwich structure, providing a promising approach for the detection of miRNA-21 in practical applications.
An electrochemical biosensor for double-stranded Wnt7B gene detection based on enzymatic isothermal amplification.
...
1
2
...

References

SHOWING 1-10 OF 55 REFERENCES
In situ amplified electronic signal for determination of low-abundance proteins coupling with nanocatalyst-based redox cycling.
Platinum-cerium oxide hybrid nanocatalysts (CeO(2)-Pt) were for the first time designed as bionanolabels for highly efficient electrochemical immunosensing of low-abundance proteins coupling
An ultrasensitive electrochemical biosensor for detection of DNA species related to oral cancer based on nuclease-assisted target recycling and amplification of DNAzyme.
A simple, label-free, ultra-highly sensitive and selective electrochemical sensor based on nuclease-assisted target recycling and DNAzyme for the detection of DNA species related to oral cancer in
Platinum nanoflower-based catalysts for an enzyme-free electrochemical immunoassay of neuron-specific enolase
Platinum nanoflowers (PtNFs) were for the first time employed as a label for a highly efficient, enzyme-free electrochemical immunoassay of neuron-specific enolase (NSE, as a model) by coupling a
A PCR based magnetic assembled sensor for ultrasensitive DNA detection.
An ultrasensitive method for DNA detection based on magnetic assembly induced by polymerase chain reaction (PCR) was developed. The sensor showed a low limit of detection (LOD) of 4.26 aM with a wide
Nucleic acid-functionalized Pt nanoparticles: Catalytic labels for the amplified electrochemical detection of biomolecules.
TLDR
The association of aptamer-functionalized Pt- NPs to a throm bin aptamer/thrombin complex associated with an electrode allowed the amplified, electrocatalytic detection of thrombin with a sensitivity limit corresponding to 1 x 10(-9) M.
Sequence-specific detection of femtomolar DNA via a chronocoulometric DNA sensor (CDS): effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes.
TLDR
It is demonstrated that the incorporation of a gold nanoparticle in this sensor design significantly enhanced the sensitivity and the selectivity, and this novel DNA sensor showed fairly good reproducibility, stability, and reusability.
DNA fuel for free-running nanomachines.
We describe kinetic control of DNA hybridization: loop complexes are used to inhibit the hybridization of complementary oligonucleotides; rationally designed DNA catalysts are shown to be effective
Amplified fluorescence determination of microRNAs in homogeneous solution with cationic conjugated polymers.
TLDR
A sensitive, selective and homogeneous method for miRNA determination has been developed based on a fluorescence resonance energy transfer (FRET) mechanism.
Cerium oxide-triggered 'one-to-many' catalytic cycling strategy for in situ amplified electronic signal of low-abundance protein.
TLDR
The thionine-modified cerium oxide nanostructures with redox ability and catalytic activity were designed as the bionanolabels for in situ amplified electronic signal of low-abundance protein and exhibited a wide linear range under optimized conditions.
...
1
2
3
4
5
...