Scaling pharmacodynamics from in vitro and preclinical animal studies to humans.

  title={Scaling pharmacodynamics from in vitro and preclinical animal studies to humans.},
  author={Donald E Mager and Sukyung Woo and William J. Jusko},
  journal={Drug metabolism and pharmacokinetics},
  volume={24 1},
An important feature of mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) models is the identification of drug- and system-specific factors that determine the intensity and time-course of pharmacological effects. This provides an opportunity to integrate information obtained from in vitro bioassays and preclinical pharmacological studies in animals to anticipate the clinical and adverse responses to drugs in humans. The fact that contemporary PK/PD modeling continues to evolve and seeks… CONTINUE READING
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The role of mechanism-based pharmacokinetic-pharmacodynamic (PK- PD) modelling in translational research of biologics

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