Scaling behavior and structure of denatured proteins.

@article{Ding2005ScalingBA,
  title={Scaling behavior and structure of denatured proteins.},
  author={Feng Ding and Ramesh Kumar Jha and Nikolay V. Dokholyan},
  journal={Structure},
  year={2005},
  volume={13 7},
  pages={
          1047-54
        }
}
An ensemble of random-coil conformations with no persistent structures has long been accepted as the classical model of denatured proteins due to its consistency with the experimentally determined scaling of protein sizes. However, recent NMR spectroscopy studies on proteins at high chemical denaturant concentrations suggest the presence of significant amounts of native-like structures, in contrast to the classical random-coil picture. To reconcile these seemingly controversial observations, we… CONTINUE READING

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Domain swapping is a consequence of minimal frustration.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004