Scale-up of high shear granulation based on the internal stress measurement.

  title={Scale-up of high shear granulation based on the internal stress measurement.},
  author={Satoru Watano and Takumi Okamoto and Yoshinobu Sato and Yoshifumi Osako},
  journal={Chemical \& pharmaceutical bulletin},
  volume={53 4},
Scale-up of wet granulation in a vertical high shear mixer was conducted. Pharmaceutical excipient powders composed of lactose, cornstarch and micro-crystallinecellulose, and hydroxypropylcellulose as a binder were mixed together and then granulated with purified water under various operating conditions and vessel scales. A novel internal stress measurement system was developed and stress of normal and tangential directions that granules received from the agitator blade during the granulation… 
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