Scale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats

@inproceedings{Raigani2017ScaleUA,
  title={Scale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats},
  author={Mozhgan Raigani and Mohammadreza Rouini and Ali-Akbar Golabchifar and Esmat Mirabzadeh and Behrouz Vaziri and Farzaneh Barkhordari and Fatemeh Davami and Fereidoun Mahboudi},
  booktitle={Scientific reports},
  year={2017}
}
Because of high mortality caused by cardiovascular diseases, various fibrinolytic agents with diverse pharmacokinetic and pharmacodynamic properties have been developed. A novel mutated chimeric tissue plasminogen activator (mt-PA) was developed by the removal of first three domains of t-PA, insertion of GHRP sequence and mutation towards resistance to… CONTINUE READING