Scale-up analysis for a CHO cell culture process in large-scale bioreactors.

Abstract

Bioprocess scale-up is a fundamental component of process development in the biotechnology industry. When scaling up a mammalian cell culture process, it is important to consider factors such as mixing time, oxygen transfer, and carbon dioxide removal. In this study, cell-free mixing studies were performed in production scale 5,000-L bioreactors to evaluate… (More)
DOI: 10.1002/bit.22287

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