Scale Reduction of a Systems Coagulation Model With an Application to Modeling Pharmacokinetic–Pharmacodynamic Data

@inproceedings{Gulati2014ScaleRO,
  title={Scale Reduction of a Systems Coagulation Model With an Application to Modeling Pharmacokinetic–Pharmacodynamic Data},
  author={Anisha Gulati and Geoffrey K Isbister and Stephen B. Duffull},
  booktitle={CPT: pharmacometrics & systems pharmacology},
  year={2014}
}
Bridging systems biology and pharmacokinetics-pharmacodynamics has resulted in models that are highly complex and complicated. They usually contain large numbers of states and parameters and describe multiple input-output relationships. Based on any given data set relating to a specific input-output process, it is possible that some states of the system are either less important or have no influence at all. In this study, we explore a simplification of a systems pharmacology model of the… CONTINUE READING