Scalable production of embryonic stem cell-derived cardiomyocytes.

@article{Zandstra2003ScalablePO,
  title={Scalable production of embryonic stem cell-derived cardiomyocytes.},
  author={Peter W. Zandstra and Celine L Bauwens and Ting Yin and Qihai Liu and Hilmar Schiller and Robert Zweigerdt and Kishore B. S. Pasumarthi and Loren Field},
  journal={Tissue engineering},
  year={2003},
  volume={9 4},
  pages={767-78}
}
Cardiomyocyte transplantation could offer a new approach to replace scarred, nonfunctional myocardium in a diseased heart. Clinical application of this approach would require the ability to generate large numbers of donor cells. The purpose of this study was to develop a scalable, robust, and reproducible process to derive purified cardiomyocytes from genetically engineered embryonic stem (ES) cells. ES cells transfected with a fusion gene consisting of the alpha-cardiac myosin heavy chain (MHC… CONTINUE READING

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