Scalable production of embryonic stem cell-derived cardiomyocytes.

  title={Scalable production of embryonic stem cell-derived cardiomyocytes.},
  author={Peter W. Zandstra and Celine L Bauwens and Ting Yin and Qihai Liu and Hilmar Schiller and Robert Zweigerdt and Kishore B. S. Pasumarthi and Loren Field},
  journal={Tissue engineering},
  volume={9 4},
Cardiomyocyte transplantation could offer a new approach to replace scarred, nonfunctional myocardium in a diseased heart. Clinical application of this approach would require the ability to generate large numbers of donor cells. The purpose of this study was to develop a scalable, robust, and reproducible process to derive purified cardiomyocytes from genetically engineered embryonic stem (ES) cells. ES cells transfected with a fusion gene consisting of the alpha-cardiac myosin heavy chain (MHC… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 89 extracted citations

Embryonic stem cells in predictive cardiotoxicity: laser capture microscopy enables assay development.

Toxicological sciences : an official journal of the Society of Toxicology • 2006
View 3 Excerpts
Highly Influenced

Bioengineered Cardiac Tissue Based on Human Stem Cells for Clinical Application.

Advances in biochemical engineering/biotechnology • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…