Scalable culture systems using different cell lines for the production of Peste des Petits ruminants vaccine.

@article{Silva2008ScalableCS,
  title={Scalable culture systems using different cell lines for the production of Peste des Petits ruminants vaccine.},
  author={Ana Carina Silva and In{\^e}s Delgado and Marcos F Q Sousa and Manuel J. T. Carrondo and Paula M. Alves},
  journal={Vaccine},
  year={2008},
  volume={26 26},
  pages={3305-11}
}
Peste des Petits ruminants (PPR) is considered as one of the major constraints to the productivity of small ruminants in Africa and Asian countries. Currently PPR control is done by vaccination with an attenuated PPR strain (Nigeria 75/1) produced in monolayers of Vero cells grown in roller bottles or static flasks. This work focuses on the production of a PPR vaccine strain using stirred conditions as an advanced option for process scale-up. Non-porous microcarriers (Cytodex-1) were used to… CONTINUE READING