Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials

  title={Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials},
  author={Tera M. Filion and Jie Song},
Over 40% of the disabling medical conditions of persons aged 18 years and over are musculoskeletal related. This number is even higher within the older population (Weinstein, 2000). Surgical treatment for age-, traumaor cancer-induced critical-size bone loss is particularly challenging. Current grafting material options for scaffold-assisted surgical repair of critical-size bone loss include autogenic bone grafts (autografts), allogenic bone grafts (allografts), and synthetic bone substitutes… 
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