Scaffolds are ‘active’ regulators of signaling modules

@article{Alexa2010ScaffoldsA,
  title={Scaffolds are ‘active’ regulators of signaling modules},
  author={Anita Alexa and J{\'a}nos Varga and Attila Rem{\'e}nyi},
  journal={The FEBS Journal},
  year={2010},
  volume={277}
}
Signaling cascades, in addition to proteins with obvious signaling‐relevant activities (e.g. protein kinases or receptors), also employ dedicated ‘inactive’ proteins whose functions appear to be the organization of the former components into higher order complexes through protein–protein interactions. The core function of signaling adaptors, anchors and scaffolds is the recruitment of proteins into one macromolecular complex. Several recent studies have demonstrated that the recruiter and the… Expand

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