Scaffolding the expansion of autophagosomes.


The conjugation of the small ubiquitin (Ub)-like protein Atg8 to autophagic membranes is a key step during the expansion of phagophores. This reaction is driven by 2 interconnected Ub-like conjugation systems. The second system conjugates the Ub-like protein Atg12 to Atg5. The resulting conjugate catalyzes the covalent attachment of Atg8 to membranes. Atg12… (More)
DOI: 10.4161/auto.28980

Cite this paper

@article{Kaufmann2014ScaffoldingTE, title={Scaffolding the expansion of autophagosomes.}, author={Anna Kaufmann and Thomas Wollert}, journal={Autophagy}, year={2014}, volume={10 7}, pages={1343-5} }