Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase

@article{Ischenko2003ScaffoldingPG,
  title={Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase},
  author={Irene Ischenko and Oleksi Petrenko and Haihua Gu and Michael J Hayman},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={6311-6318}
}
Transformation of fibroblasts by V-SEA involves activation of the ERK and phosphatidylinositol 3-kinase (PI3K) pathways. Effector proteins that are key mediators of the ERK and PI3K pathways, namely Grb2, the tyrosine phosphatase, SHP2 and PI3K, interact with the two phosphotyrosines found in the bidentate motif in the carboxy-terminal region of V-SEA… CONTINUE READING