Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling

  title={Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling},
  author={Jesse Eunsuk Jun and Christopher C. Goodnow},
  journal={Nature Immunology},
Lymphocyte antigen receptors are responsible for inducing the opposite responses of immunity or tolerance. How the correct polarity of antigen receptor signaling is encoded has been an enduring enigma. Here we summarize recent advances defining key scaffolding molecules, CARMA1 (also known as CARD11) and the Cbl family of ubiquitin ligases, required for either immunogenic or tolerogenic signaling by antigen receptors. These scaffolding proteins may determine the polarity of response to antigen… CONTINUE READING


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DOCK 2 is essential for antigeninduced translocation of TCR and lipid rafts , but not PKCtheta and LFA - 1 , in T Cells

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