Scaffold stiffness affects the contractile function of three-dimensional engineered cardiac constructs.

Abstract

We investigated the effects of the initial stiffness of a three-dimensional elastomer scaffold--highly porous poly(glycerol sebacate)--on functional assembly of cardiomyocytes cultured with perfusion for 8 days. The polymer elasticity varied with the extent of polymer cross-links, resulting in three different stiffness groups, with compressive modulus of 2… (More)
DOI: 10.1002/btpr.435

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