Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2.

@article{Nakatani2016ScaffoldPE,
  title={Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2.},
  author={Miyuki Nakatani and Jumpei Ito and Riko Koyama and Masumi Iijima and Nobuo Yoshimoto and Tomoaki Niimi and Shun' Ichi Kuroda and Andr{\'e}s Daniel Maturana},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={474 2},
  pages={413-420}
}
Enigma Homolog 1 (ENH1) is a scaffold protein for signaling proteins and transcription factors. Previously, we reported that ENH1 overexpression promotes the differentiation of C2C12 myoblasts. However, the molecular mechanism underlying the role of ENH1 in the C2C12 cells differentiation remains elusive. ENH1 was shown to inhibit the proliferation of neuroblastoma cells by sequestering Inhibitor of DNA binding protein 2 (Id2) in the cytosol. Id2 is a repressor of basic Helix-Loop-Helix… CONTINUE READING
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