Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors

@inproceedings{Andersen2013ScaffoldNN,
  title={Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors},
  author={Kasper R\ojkj{\ae}r Andersen and Evgeny Onischenko and Jeffrey H Tang and Pravin Kumar and James Z. Chen and Alexander Ulrich and Jan T. Liphardt and Karsten Weis and Thomas U Schwartz},
  booktitle={eLife},
  year={2013}
}
Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs) embedded in the nuclear envelope. About 30 different proteins (nucleoporins, nups) arrange around a central eightfold rotational axis to build the modular NPC. Nup188 and Nup192 are related and evolutionary conserved, large nucleoporins that are part of the NPC scaffold. Here we determine the structure of Nup188. The protein folds into an extended stack of helices where an N-terminal 130 kDa segment forms an intricate… CONTINUE READING
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