Scaffold-free in vitro arterial mimetics: the importance of smooth muscle-endothelium contact.

Abstract

We have developed an in vitro endothelial cell (EC)-smooth muscle cell (SMC) coculture platform that can mimic either the healthy or diseased state of blood vessels. Transforming growth factor-beta1 (TGF-beta1) and heparin were introduced to the SMC cultures to upregulate the SMC differentiation markers, alpha-smooth muscle actin (alpha-SMA) and calponin… (More)
DOI: 10.1089/ten.TEA.2009.0271

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