Scaffold-free high throughput generation of quiescent valvular microtissues.

  title={Scaffold-free high throughput generation of quiescent valvular microtissues.},
  author={Annelies Roosens and In{\`e}s Puype and R. L. Cornelissen},
  journal={Journal of molecular and cellular cardiology},
AIMS The major challenge of working with valvular interstitial cells in vitro is the preservation or recovery of their native quiescent state. In this study, a biomimetic approach is used which aims to engineer small volume, high quality valve microtissues, having a potential in regenerative medicine and as a relevant 3D in vitro model to provide insights into valve (patho)biology. METHODS AND RESULTS To form micro-aggregates, porcine valvular interstitial cells were seeded in agarose micro… CONTINUE READING


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