Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

@inproceedings{Hegde2016ScaffoldAF,
  title={Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions},
  author={Muralidhar L Hegde and Arijit Dutta and Chunying Yang and Anil K. Mantha and Pavana M Hegde and Arvind Pandey and Shiladitya Sengupta and Yaping Yu and Patrick Calsou and David J. Chen and Susan P Lees-Miller and Sankar Mitra},
  booktitle={Oncotarget},
  year={2016}
}
Ionizing radiation (IR) induces highly cytotoxic double-strand breaks (DSBs) and also clustered oxidized bases in mammalian genomes. Base excision repair (BER) of bi-stranded oxidized bases could generate additional DSBs as repair intermediates in the vicinity of direct DSBs, leading to loss of DNA fragments. This could be avoided if DSB repair via DNA-PK-mediated nonhomologous end joining (NHEJ) precedes BER initiated by NEIL1 and other DNA glycosylases (DGs). Here we show that DNA-PK subunit… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…