Sca1(+) mesenchymal stromal cells inhibit graft-versus-host disease in mice after bone marrow transplantation.

@article{Wen2015Sca1MS,
  title={Sca1(+) mesenchymal stromal cells inhibit graft-versus-host disease in mice after bone marrow transplantation.},
  author={Fan Wen and Huijie Zhang and Yaozhen Chen and Qiaohong Yue and Zheng Xia Liu and Qingping Zhang and Ning An and Xiaopeng Chen and Na Li and Jiajia Xin and Yazhou Wang and Xianqing Zhang and Xueqing Xu and Xing-bin Hu},
  journal={International immunopharmacology},
  year={2015},
  volume={26 1},
  pages={50-7}
}
Mesenchymal stromal cells (MSCs) have therapeutic potential for the prevention and treatment of graft-versus-host disease (GVHD). However, MSCs comprise several subpopulations, which have not been individually assessed for their role in GVHD suppression. In this study, we assessed the immunosuppressive effect of bone-related Sca1(+) MSCs on acute GVHD in a… CONTINUE READING