Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation.

@article{Heard2016Sc65NullMP,
  title={Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation.},
  author={Melissa E Heard and Roberta Besio and Maryann Weis and Jyoti Rai and David M Hudson and Milena Dimori and Sarah M. Zimmerman and Jeffrey A Kamykowski and William R. Hogue and Frances L. Swain and Marie Schluterman Burdine and Samuel G. Mackintosh and Alan J. Tackett and Larry J. Suva and David R Eyre and Roy Morello},
  journal={PLoS genetics},
  year={2016},
  volume={12 4},
  pages={e1006002}
}
Collagen is a major component of the extracellular matrix and its integrity is essential for connective tissue and organ function. The importance of proteins involved in intracellular collagen post-translational modification, folding and transport was recently highlighted from studies on recessive forms of osteogenesis imperfecta (OI). Here we describe the critical role of SC65 (Synaptonemal Complex 65, P3H4), a leprecan-family member, as part of an endoplasmic reticulum (ER) complex with… CONTINUE READING
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