SbcC-SbcD and ExoI process convergent forks to complete chromosome replication

@article{Wendel2017SbcCSbcDAE,
  title={SbcC-SbcD and ExoI process convergent forks to complete chromosome replication},
  author={Brian M Wendel and Jessica M Cole and C. T. Courcelle and J. Courcelle},
  journal={Proceedings of the National Academy of Sciences},
  year={2017},
  volume={115},
  pages={349 - 354}
}
Significance SbcC-SbcD and ExoI belong to a class of highly conserved nucleases that are critical to genome stability, but whose cellular function remains poorly understood. Human homologs of these proteins are essential for viability and normal development, and lead to severe developmental abnormalities and cancer predisposition when mutated. Here we show that these enzymes process DNA intermediates at sites where replication forks converge and are required for chromosome replication to… Expand
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