SbcC-SbcD and ExoI process convergent forks to complete chromosome replication.

@article{Wendel2018SbcCSbcDAE,
  title={SbcC-SbcD and ExoI process convergent forks to complete chromosome replication.},
  author={Brian M Wendel and Jessica M Cole and Charmain Tan Courcelle and Justin Courcelle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2018},
  volume={115 2},
  pages={
          349-354
        }
}
SbcC-SbcD are the bacterial orthologs of Mre11-Rad50, a nuclease complex essential for genome stability, normal development, and viability in mammals. In vitro, these enzymes degrade long DNA palindromic structures. When inactivated along with ExoI in Escherichia coli, or Sae2 in eukaryotes, palindromic amplifications arise and propagate in cells. However… CONTINUE READING