Say NO to hypoperfusion!

@article{Duncker2009SayNT,
  title={Say NO to hypoperfusion!},
  author={Dirk Jan Duncker and Daphne Merkus},
  journal={Journal of applied physiology},
  year={2009},
  volume={107 6},
  pages={
          1680-2
        }
}
  • D. Duncker, D. Merkus
  • Published 1 December 2009
  • Medicine, Engineering, Biology
  • Journal of applied physiology
AUTOREGULATION is defined as the capacity of an organ or tissue to maintain a constant blood flow in the face of a change in perfusion pressure, while metabolism is unchanged. Under normal physiological conditions, large proximal arteries contribute little to the total resistance of a particular vascular bed. However, when atherosclerosis causes a conductance artery to narrow so that over 70% of the luminal cross-sectional area becomes obliterated, such a stenosis results in a significant… 
2 Citations
Protection against skeletal muscle hypoperfusion by adenosine and nitric oxide: together alone?
TLDR
regulation of vasomotor tone in the microcirculation is essential to ensure adequate tissue oxygenation, particularly when oxygen demand is high, i.e., during hypoxia or in the presence of a flow-limiting stenosis.

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