Saxagliptin affects long-bone microarchitecture and decreases the osteogenic potential of bone marrow stromal cells.

@article{Sbaraglini2014SaxagliptinAL,
  title={Saxagliptin affects long-bone microarchitecture and decreases the osteogenic potential of bone marrow stromal cells.},
  author={Mar{\'i}a L. Sbaraglini and Mar{\'i}a Silvina Molinuevo and Claudia Sedlinsky and Le{\'o}n Schurman and Antonio Desmond McCarthy},
  journal={European journal of pharmacology},
  year={2014},
  volume={727},
  pages={
          8-14
        }
}
Diabetes mellitus is associated with a decrease in bone quality and an increase in fracture incidence. Additionally, treatment with anti-diabetic drugs can either adversely or positively affect bone metabolism. In this study we evaluated: the effect of a 3-week oral treatment with saxagliptin on femoral microarchitecture in young male non-type-2-diabetic Sprague Dawley rats; and the in vitro effect of saxagliptin and/or fetal bovine serum (FBS), insulin or insulin-like growth factor-1 (IGF1… CONTINUE READING

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