Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone.

@article{Hollander2009SaxagliptinAT,
  title={Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone.},
  author={Priscilla A. Hollander and Jia Li and Elsie Allen and Roland Chen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2009},
  volume={94 12},
  pages={4810-9}
}
CONTEXT Due to the natural progression of type 2 diabetes (T2D), most patients require combination therapy to maintain glycemic control. OBJECTIVE Our objective was to evaluate efficacy and safety of saxagliptin plus thiazolidinedione (TZD) in patients with T2D and inadequate glycemic control on TZD monotherapy. DESIGN The study was a multicenter, randomized, double-blind, placebo (PBO)-controlled phase 3 trial conducted from March 13, 2006, to October 15, 2007. SETTING Patients were… CONTINUE READING
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