Saxagliptin Restores Vascular Mitochondrial Exercise Response in the Goto-Kakizaki Rat

@inproceedings{Keller2015SaxagliptinRV,
  title={Saxagliptin Restores Vascular Mitochondrial Exercise Response in the Goto-Kakizaki Rat},
  author={Amy C. Keller and Leslie A. Knaub and Matthew W. Miller and Nicholas Birdsey and Dwight J. Klemm and Jane E B Reusch},
  booktitle={Journal of cardiovascular pharmacology},
  year={2015}
}
Cardiovascular disease risk and all-cause mortality are largely predicted by physical fitness. Exercise stimulates vascular mitochondrial biogenesis through endothelial nitric oxide synthase (eNOS), sirtuins, and PPARγ coactivator 1α (PGC-1α), a response absent in diabetes and hypertension. We hypothesized that an agent regulating eNOS in the context of diabetes could reconstitute exercise-mediated signaling to mitochondrial biogenesis. Glucagon-like peptide 1 (GLP-1) stimulates eNOS and blood… CONTINUE READING

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