Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy

@inproceedings{Chang2017SaxagliptinAA,
  title={Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy},
  author={Yun-peng Chang and Bei Sun and Zhe Han and Fei Han and Shao-lan Hu and Xiaoyu Li and Mei Xue and Yang Yang and Li Chen and Chun-jun Li and Li-ming Chen},
  booktitle={Front. Pharmacol.},
  year={2017}
}
The dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin has been found to reduce progressive albuminuria, but the exact mechanism of inhibition is unclear. Podocyte epithelial-to-mesenchymal transition (EMT) has emerged as a potential pathway leading to proteinuria in diabetic nephropathy (DN). Stromal cell-derived factor-1α (SDF-1α), one of the substrates of DPP-4, can activate the protein kinase A pathway and subsequently inhibit its downstream effector, transforming growth factor-β1 (TGF-β1… CONTINUE READING
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