Savignygrin, a Platelet Aggregation Inhibitor from the Soft TickOrnithodoros savignyi, Presents the RGD Integrin Recognition Motif on the Kunitz-BPTI Fold*

@article{Mans2002SavignygrinAP,
  title={Savignygrin, a Platelet Aggregation Inhibitor from the Soft TickOrnithodoros savignyi, Presents the RGD Integrin Recognition Motif on the Kunitz-BPTI Fold*},
  author={B. Mans and A. Louw and A. Neitz},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={21371 - 21378}
}
Savignygrin, a platelet aggregation inhibitor that possesses the RGD integrin recognition motif, has been purified from the soft tick Ornithodoros savignyi. Two isoforms with similar biological activities differ because of R52G and N60G in their amino acid sequences, indicating a recent gene duplication event. Platelet aggregation induced by ADP (IC50, 130 nm), collagen, the thrombin receptor-activating peptide, and epinephrine was inhibited, although platelets were activated and underwent a… Expand
The mechanism of αIIbβ3 antagonism by savignygrin and its implications for the evolution of anti-hemostatic strategies in soft ticks
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Disagregin is a fibrinogen receptor antagonist lacking the Arg-Gly-Asp sequence from the tick, Ornithodoros moubata.
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Disagregin is unique both in structure and function and may serve as a useful tool for the design of therapeutically useful antithrombotic agents. Expand
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Data demonstrate that disagregin binds to GPIIb-IIIa through a mechanism distinct from that used by RGD-containing disintegrins, and should provide useful information for molecular modeling of the fibrinogen binding site on GP IIb- IIIa and for the design of a new class of potent fibr inogen receptor antagonists. Expand
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A novel inhibitor of human platelet aggregation, named variabilin, was isolated from salivary glands of the hard tick Dermacentor variabilis using a combination of gel filtration and high pressure liquid chromatography, and is the first RGD-containing antagonist isolated from ticks. Expand
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The results suggest the presence of two or more anti-platelet factors present in the salivary glands of this tick species. Expand
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