Sauvagine, a new polypeptide from Phyllomedusa sauvagei skin

@article{Erspamer2004SauvagineAN,
  title={Sauvagine, a new polypeptide from Phyllomedusa sauvagei skin},
  author={Vittorio Erspamer and Giuliana Falconieri Erspamer and Giovanna Improta and Lucia Negri and Roberto de Castiglione},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={312},
  pages={265-270}
}
Summary1.The occurrence of sauvagine, a new polypeptide from amphibian skin, and its actions on rat blood pressure and diuresis were studied.2.Sauvagine was found to be present in the skin of all the 10 Phyllomedusa species so far studied, amounts ranging from a few micrograms to 240 μg per g fresh skin.3.The polypeptide displayed in the rat an intense, long-lasting hypotensive action accompanied by tachycardia. Hypotension was not modified by either atropine or propranolol, excluding the… Expand
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The skin of the South American frog Phyllomedusa sauvagei contains a new active polypeptide, sauvagine, which does not belong to any of the peptide families hitherto described in the amphibian skin.Expand
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