Sauchinone inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocytes to attenuate osteoarthritis via Nrf2/HO-1 and NF-κB pathways.

@article{Wu2018SauchinoneII,
  title={Sauchinone inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocytes to attenuate osteoarthritis via Nrf2/HO-1 and NF-κB pathways.},
  author={Dengying Wu and ShanShan Jin and Zeng Lin and Rong Chen and Tianlong Pan and Xiaodiao Kang and Huasong Huang and Cong Lin and Jun Pan},
  journal={International immunopharmacology},
  year={2018},
  volume={62},
  pages={
          181-190
        }
}
BACKGROUND Osteoarthritis (OA) is a common degenerative joint disease for which currently no anti-inflammatory therapy is available. Sauchinone (SAU), a key bioactive compound derived from Saururus chinensis, which has shown remarkable anti-inflammatory effects. METHODS To evaluate the effect of SAU on OA progression, mouse chondrocytes were pretreated with SAU and subsequently stimulated with interleukin (IL)-1β. We found that SAU reduced the production of pro-inflammatory cytokines, such as… CONTINUE READING
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