Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus.

@article{Shedlovsky1988SaturationGL,
  title={Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus.},
  author={Alexandra Shedlovsky and Thomas King and William F Dove},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 1},
  pages={180-4}
}
The proximal region of mouse chromosome 17 contains many genes affecting embryonic development, germ cell differentiation, and the immune system. Although the study of natural variation, including t haplotypes, has yielded some information about the function of these genes, spontaneous variants often exhibit manifold genetic effects and are generally not carried on inbred backgrounds. To clearly connect phenotypes with the actions of individual genes, mutants in which genes are altered singly… CONTINUE READING

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