Saturated fatty acids trigger TLR4-mediated inflammatory response.

  title={Saturated fatty acids trigger TLR4-mediated inflammatory response.},
  author={Daniela Mayumi Usuda Prado Rocha and Ana Paula Silva Caldas and Leandro Licursi de Oliveira and Josefina Bressan and Helen Hermana Miranda Hermsdorff},
Toll-like receptors (TLR) mediate infection-induced inflammation and sterile inflammation by endogenous molecules. Among the TLR family, TLR4 is the best understood. However, while its downstream signaling pathways have been well defined, not all ligands of TLR4 are currently known. Current evidence suggests that saturated fatty acids (SFA) act as non-microbial TLR4 agonists, and trigger its inflammatory response. Thus, our present review provides a new perspective on the potential mechanism by… CONTINUE READING
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