Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.

@article{Ruddock2008SaturatedFA,
  title={Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.},
  author={Mark W. Ruddock and Andrew Stein and Edwin J Landaker and Jun Gi Park and Robert C. Cooksey and Donald McClain and M F Patti},
  journal={Journal of biochemistry},
  year={2008},
  volume={144 5},
  pages={599-607}
}
Free fatty acids (FFAs) are proposed to play a pathogenic role in both peripheral and hepatic insulin resistance. We have examined the effect of saturated FFA on insulin signalling (100 nM) in two hepatocyte cell lines. Fao hepatoma cells were treated with physiological concentrations of sodium palmitate (0.25 mM) (16:0) for 0.25-48 h. Palmitate decreased insulin receptor (IR) protein and mRNA expression in a dose- and time-dependent manner (35% decrease at 12 h). Palmitate also reduced insulin… CONTINUE READING

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