Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications.

@article{Kennedy2009SaturatedFA,
  title={Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications.},
  author={Arion J Kennedy and Kristina Martinez and Chia-Chi Chuang and Kathleen Lapoint and M. K. Mcintosh},
  journal={The Journal of nutrition},
  year={2009},
  volume={139 1},
  pages={
          1-4
        }
}
This review highlights the inflammatory and insulin-antagonizing effects of saturated fatty acids (SFA), which contribute to the development of metabolic syndrome. Mechanisms responsible for these unhealthy effects of SFA include: 1) accumulation of diacylglycerol and ceramide; 2) activation of nuclear factor-kappaB, protein kinase C-, and mitogen-activated protein kinases, and subsequent induction of inflammatory genes in white adipose tissue, immune cells, and myotubes; 3) decreased PPARgamma… 

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