Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

@article{Cao2011SaturatedFA,
  title={Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway},
  author={Jie Cao and Dong-ling Dai and Long Yao and Hui-hong Yu and Bo Ning and Qin Zhang and Juan Chen and Wen-hui Cheng and Wei Shen and Zhao-xia Yang},
  journal={Molecular and Cellular Biochemistry},
  year={2011},
  volume={364},
  pages={115-129}
}
Accumulation of saturated fatty acids in the liver can cause nonalcoholic fatty liver disease (NAFLD). This study investigated saturated fatty acid induction of endoplasmic reticulum (ER) stress and apoptosis in human liver cells and the underlying causal mechanism. Human liver L02 and HepG2 cell lines were exposed to the saturated fatty acid sodium palmitate. MTT assay was used for cell viability, flow cytometry and Hoechst 33258 staining for apoptosis, RT-PCR for mRNA expression, and Western… CONTINUE READING
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