Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells.

@article{Hirabara2010SaturatedFA,
  title={Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells.},
  author={Sandro Massao Hirabara and R. A. Curi and Pierre Maechler},
  journal={Journal of cellular physiology},
  year={2010},
  volume={222 1},
  pages={187-94}
}
Increased plasma levels of free fatty acids (FFA) occur in states of insulin resistance such as obesity and type 2 diabetes mellitus. These high levels of plasma FFA are proposed to play an important role for the development of insulin resistance but the mechanisms involved are still unclear. This study investigated the effects of saturated and unsaturated FFA on insulin sensitivity in parallel with mitochondrial function. C2C12 myotubes were treated for 24 h with 0.1 mM of saturated (palmitic… CONTINUE READING