Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin.

@article{Hardy2003SaturatedFA,
  title={Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin.},
  author={Serge Hardy and Wissal El-Assaad and Ewa Przybytkowski and Erik Joly and Marc Prentki and Yves Langelier},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 34},
  pages={31861-70}
}
Little is known about the biochemical basis of the action of free fatty acids (FFA) on breast cancer cell proliferation and apoptosis. Here we report that unsaturated FFAs stimulated the proliferation of human MDA-MB-231 breast cancer cells, whereas saturated FFAs inhibited it and caused apoptosis. Saturated FFA palmitate decreased the mitochondrial membrane potential and caused cytochrome c release. Palmitate-induced apoptosis was enhanced by the fat oxidation inhibitor etomoxir, whereas it… CONTINUE READING

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