Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine.

  title={Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine.},
  author={Nicole J. W. de Wit and Muriel Derrien and Hanneke Bosch-Vermeulen and Els Oosterink and Shohreh Keshtkar and Caroline Duval and Johan de Vogel-van den Bosch and Michiel Kleerebezem and Michael M{\"u}ller and Roelof van der Meer},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={303 5},
We studied the effect of dietary fat type, varying in polyunsaturated-to-saturated fatty acid ratios (P/S), on development of metabolic syndrome. C57Bl/6J mice were fed purified high-fat diets (45E% fat) containing palm oil (HF-PO; P/S 0.4), olive oil (HF-OO; P/S 1.1), or safflower oil (HF-SO; P/S 7.8) for 8 wk. A low-fat palm oil diet (LF-PO; 10E% fat) was used as a reference. Additionally, we analyzed diet-induced changes in gut microbiota composition and mucosal gene expression. The HF-PO… 

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