Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions

  title={Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions},
  author={Aseem Malhotra and Rita F. Redberg and Pascal Meier},
  journal={British Journal of Sports Medicine},
  pages={1111 - 1112}
Coronary artery disease pathogenesis and treatment urgently requires a paradigm shift. Despite popular belief among doctors and the public, the conceptual model of dietary saturated fat clogging a pipe is just plain wrong. A landmark systematic review and meta-analysis of observational studies showed no association between saturated fat consumption and (1) all-cause mortality, (2) coronary heart disease (CHD), (3) CHD mortality, (4) ischaemic stroke or (5) type 2 diabetes in healthy adults.1… 
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Those on a low-carbohydrate weight-loss diet who increase their percentage intake of dietary saturated fat may improve their overall lipid profile provided they focus on a high-quality diet and lower their intakes of both calories and refined carbohydrates.
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  • 2021
The number of high-quality studies on fatty acids is large enough to make useful recommendations on clinical application and everyday practice and the targeted use of long chain ω3 fatty acids based on blood analysis has great potential to supplement or even be an alternative to various pharmacological therapies.
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Compared with drug therapy alone, coronary stent intervention therapy has better clinical efficacy and short-term and long-term prognosis in treating CHD, but it is easy to promote inflammatory reaction after surgery.
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Saturated fats are not associated with all cause mortality, CVD, CHD, ischemic stroke, or type 2 diabetes, but the evidence is heterogeneous with methodological limitations, and Dietary guidelines must carefully consider the health effects of recommendations for alternative macronutrients to replace trans fats and saturated fats.
Dietary fats, carbohydrate, and progression of coronary atherosclerosis in postmenopausal women.
In postmenopausal women with relatively low total fat intake, a greater saturated fat intake is associated with less progression of coronary atherosclerosis, whereas carbohydrate intake isassociated with a greater progression.
Dietary fatty acids in the secondary prevention of coronary heart disease: a systematic review, meta-analysis and meta-regression
The present systematic review provides no evidence (moderate quality evidence) for the beneficial effects of reduced/modified fat diets in the secondary prevention of coronary heart disease.
Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)
Evidence from randomized controlled trials shows that replacement of saturated fat in the diet with linoleic acid effectively lowers serum cholesterol but does not support the hypothesis that this translates to a lower risk of death from coronary heart disease or all causes.
Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review
High LDL-C is inversely associated with mortality in most people over 60 years, which is inconsistent with the cholesterol hypothesis (ie, that cholesterol, particularly HDL-C, is inherently atherogenic).
Review: Nutriceuticals as antithrombotic agents.
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Coronary artery disease as clogged pipes: a misconceptual model.
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  • Medicine
    Circulation. Cardiovascular quality and outcomes
  • 2013
Although the image of coronary arteries as kitchen pipes clogged with fat is simple, familiar, and evocative, it is also wrong.
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