Saturated Reconstruction of a Volume of Neocortex

@article{Kasthuri2015SaturatedRO,
  title={Saturated Reconstruction of a Volume of Neocortex},
  author={Narayanan Kasthuri and Kenneth Jeffrey Hayworth and Daniel R. Berger and Richard Schalek and Jos{\'e} Angel Conchello and Seymour Knowles-Barley and Dongil Lee and Amelio V{\'a}zquez-Reina and Verena Kaynig and Thouis Raymond Jones and Mike Roberts and Josh L. Morgan and Juan Carlos Tapia and H. Sebastian Seung and William Gray Roncal and Joshua T. Vogelstein and Randal Burns and Daniel Lewis Sussman and Carey E. Priebe and Hanspeter Pfister and Jeff William Lichtman},
  journal={Cell},
  year={2015},
  volume={162},
  pages={648-661}
}
We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spine apparati, postsynaptic densities, and mitochondria) are rendered and itemized in a database. We explore these data to study physical properties of brain tissue. For example, by… CONTINUE READING
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