Saturable uptake of cefixime, a new oral cephalosporin without an α‐amino group, by the rat intestine

@article{Tsuji1987SaturableUO,
  title={Saturable uptake of cefixime, a new oral cephalosporin without an $\alpha$‐amino group, by the rat intestine},
  author={A. Tsuji and H. Hirooka and T. Terasaki and I. Tamai and E. Nakashima},
  journal={Journal of Pharmacy and Pharmacology},
  year={1987},
  volume={39}
}
The mechanism of intestinal uptake of cefixime, a new oral cephalosporin antibiotic, has been examined using the everted jejunum of rats. The initial uptake rates were apparently pH‐dependent with the maximum rate at pH 5.0 and a 3‐fold reduction at pH 7.0. The uptake at pH 5.0 followed mixed‐type kinetics involving saturable and non‐saturable processes in a manner similar to that for several amino‐β‐lactam antibiotics. Cefixime uptake was inhibited significantly by 20 mM permeants such as… Expand
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