Saturable uptake of a recombinant human granulocyte colony-stimulating factor derivative, nartograstim, by the bone marrow and spleen of rats in vivo.

@article{Kuwabara1995SaturableUO,
  title={Saturable uptake of a recombinant human granulocyte colony-stimulating factor derivative, nartograstim, by the bone marrow and spleen of rats in vivo.},
  author={Toichiro Kuwabara and Takashi Uchimura and Kazuhiro Takai and Hideyuki Kobayashi and Satoru Kobayashi and Yuichi Sugiyama},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={273 3},
  pages={1114-22}
}
Kinetic analysis of the in vivo tissue distribution of the recombinant human granulocyte colony-stimulating factor (rhG-CSF) derivative, nartograstim (NTG; nartograstim is an international nonproprietary name of KW-2228, Kyowa Hakko Kogyo, Tokyo, Japan) was studied in rats to determine the mechanism of the growth factor's nonlinear pharmacokinetic properties. The early-phase tissue uptake clearance (CL(uptake)) by each tissue was determined within 5 min after the i.v. administration of 125I-NTG… CONTINUE READING