Saturable transport of peptides across the blood-brain barrier.

  title={Saturable transport of peptides across the blood-brain barrier.},
  author={W. A. Banks and Abba J. Kastin},
  journal={Life sciences},
  volume={41 11},
Peptides can be transported across the blood-brain barrier by saturable transport systems. One system, characterized with radioactively labeled Tyr-MIF-1 (Tyr-Pro-Leu-Gly-amide), is specific for some of the small peptides with an N-terminal tyrosine, including Tyr-MIF-1, the enkephalins, beta-casomorphin, and dynorphin (1-8). Another separate system transports vasopressin-like peptides. The choroid plexus has at least one system distinguishable from those above that is capable of uptake and… CONTINUE READING