Saturable transport of cimetidine from cerebrospinal fluid to blood in rats.

@article{Suzuki1985SaturableTO,
  title={Saturable transport of cimetidine from cerebrospinal fluid to blood in rats.},
  author={Hiroshi Suzuki and Yasufumi Sawada and Yuichi Sugiyama and Tatsuji Iga and Manabu Hanano},
  journal={Journal of pharmacobio-dynamics},
  year={1985},
  volume={8 1},
  pages={73-6}
}
Cimetidine, a histamine H2 receptor antagonist, is known to have some effects on central nervous system, and is reported to emerge in the cerebrospinal fluid (CSF). We evaluated the elimination of cimetidine from CSF by the method of ventriculo-cisternal perfusion in rats. The extraction ratio of cimetidine at the low perfusate concentration (14 nM) was 0.190 +/- 0.023 (n = 3), while that significantly (p less than 0.02) decreased to 0.0916 +/- 0.081 (n = 3) at the high concentration (4 mM). No… CONTINUE READING