Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers.

@article{Lee1999SaturableTO,
  title={Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers.},
  author={Kiho Lee and Dhiren R. Thakker},
  journal={Journal of pharmaceutical sciences},
  year={1999},
  volume={88 7},
  pages={680-7}
}
The purpose of this study was to investigate the mechanism by which the H2-antagonists ranitidine and famotidine interacted with the paracellular space during their transport across Caco-2 cell monolayers. Transport experiments with ranitidine and famotidine across Caco-2 cell monolayers were performed to determine the apical-to-basolateral flux at various concentrations. Kinetic analysis of the transport data showed that ranitidine and famotidine were transported by both saturable and… CONTINUE READING

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