Satiation and masticatory function modulated by brain histamine in rats.

@article{Fujise1998SatiationAM,
  title={Satiation and masticatory function modulated by brain histamine in rats.},
  author={Tomoko Fujise and Hironobu Yoshimatsu and Mamoru Kurokawa and Akihiko Oohara and Minwook Kang and Mari Nakata and Toshiie Sakata},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1998},
  volume={217 2},
  pages={228-34}
}
Both the ventromedial hypothalamus (VMH) and the mesencephalic trigeminal sensory nucleus (Me5) are densely innervated by histaminergic neurons. The depletion of neuronal histamine (HA) from the Me5 by the bilateral microinfusion of 448 nmol/rat alpha-fluoromethylhistidine (FMH), a specific suicide inhibitor of histidine decarboxylase, reduced the eating speed and prolonged meal duration, while leaving the meal size unaffected. HA depletion from the VMH increased the size of the meal and… CONTINUE READING

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