Satellite III DNA: Regions of extreme endonuclease resistance and interindividual polymorphism in the Mb size range

@article{Fowler1992SatelliteID,
  title={Satellite III DNA: Regions of extreme endonuclease resistance and interindividual polymorphism in the Mb size range},
  author={Joanna C. Fowler and Leigh A. Burgoyne},
  journal={Genetica},
  year={1992},
  volume={87},
  pages={75-78}
}
Southern analysis of within-gel digested and restricted human cells has revealed very large Satellite III restriction fragments which show clear inter-individual length polymorphism. The Mb and sub-Mb length of these fragments indicate that they arise from regions of heterochromatin which contain homogeneous Satellite III sequences of peculiar resistance to common endonucleases. Based on sequence alone, such regions would be little digested by endonuclease digestion of chromatin in metaphase… CONTINUE READING