Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation

  title={Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation},
  author={K. Yasuda and Y. Kitagawa and Ryoji Kawakami and Y. Isaka and H. Watanabe and G. Kondoh and T. Kohwi-Shigematsu and S. Sakaguchi and K. Hirota},
  journal={Nature Communications},
The genome organizer, special AT-rich sequence-binding protein-1 (Satb1), plays a pivotal role in the regulation of global gene networks in a cell type-dependent manner and is indispensable for the development of multiple cell types, including mature CD4+ T, CD8+ T, and Foxp3+ regulatory T cells in the thymus. However, it remains unknown how the differentiation and effector program of the Th subsets in the periphery are regulated by Satb1. Here, we demonstrate that Satb1 differentially… Expand
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